Cerium dioxide nanoparticles may treat Parkinson's disease

Researchers have developed a new drug candidate to treat Parkinson's disease, a refractory disease.

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A team of researchers at Seoul university's school of biological sciences and biotechnology confirmed the effectiveness of a Parkinson's disease treatment using a cerium oxide nanoparticle system that removes reactive oxygen species by region.

Reactive oxygen species (ros) is a generic term for the various types of degenerated oxygen that destroy cells. Some reactive oxygen species are essential for cell survival, but in high concentrations it causes a phenomenon called "oxidative stress," but it attacks cells. Hydrogen peroxide, which kills and disinfects bacteria in hospitals, is also a reactive oxygen species. Reactive oxygen species cause aging, which affects the nervous system and causes Parkinson's disease. The problem is that even in the same Parkinson's disease, reactive oxygen species can affect neurons in different locations. Organelles in the mitochondria, and oxidative stress in the cytoplasmic generating units are the main building blocks, but the primary cause of Parkinson's, the production of free radicals on the outside of the battery also affects Parkinson's disease.

Therefore, therapeutic drugs should be used effectively according to the location of oxidative stress.

To solve this problem, professor hyun-hwanhyeon focused on a substance called cerium dioxide (CeO2). The researchers believe Celia can be used as a remedy because it effectively removes reactive oxygen species and has been working on its medical applications since six years ago. As a result, the researchers found that cerium dioxide could be used as a remedy if fine particles of nanometers (nm=10 billionths of a metre) were treated.

The researchers took this step and caused involvement in Parkinson's mitochondria, cytoplasm, and extracellular cells, thereby separating the free radicals produced in the three areas so that they were able to remove each of the three structures of the cerium oxide nanoparticles.

The researchers actually demonstrated the effectiveness of cerium dioxide particles in animal experiments using laboratory mice. Three types of cerium dioxide particles were injected after Parkinson's disease from rats; S, "the amount of tyrosine kinase hydroxyl (TH), the raw material for the neurotransmitter dopamine in the brain, rose to the same level as normal rats. Clusters of nanoparticles that have been shown to develop outside the cell reduced oxidative stress outside the brain, although TH did not decrease.

The results of the study were published on June 22 AngewandteChemieInternationalEdition international journals in the field of chemical industry.